Prognostic Value of Blood Epigenetic Biomarkers of Aging in Persons With Well-Controlled Human Immunodeficiency Virus (HIV-1) Infection
In this preliminary study, GrimAge and PC-GrimAge were associated with increased risk of adverse outcomes in people with well-controlled HIV infection. These findings suggest their potential as long-term health-risk biomarkers, warranting validation in larger cohorts.
Authors
- Leire Pérez‐Latorre (ORCID: https://orcid.org/0000-0001-9919-3778)
- Vicente Estrada (ORCID: https://orcid.org/0000-0002-7795-5986)
- José Ignacio Bernardino (ORCID: https://orcid.org/0000-0003-3501-8529)
- María Jiménez-González (ORCID: https://orcid.org/0000-0003-4925-731X)
- Rosa de Miguel Buckley (ORCID: https://orcid.org/0000-0003-2749-818X)
- Berta Rodés (ORCID: https://orcid.org/0000-0002-6037-0105)
- Lucía Gutiérrez-García (ORCID: https://orcid.org/0000-0002-7393-087X)
- Rocío Montejano (ORCID: https://orcid.org/0000-0002-3446-0545)
- José Ramón Arribas (ORCID: https://orcid.org/0000-0002-7410-9450)
- Pablo Ryan (ORCID: https://orcid.org/0000-0002-4212-7419)
- Alejandro Vidal (ORCID: https://orcid.org/0000-0003-2609-2559)
- Cristina Marcelo (ORCID: https://orcid.org/0000-0002-6187-7442)
- Juan Emilio Losa (ORCID: https://orcid.org/0000-0002-0750-0185)
- María del Mar Arcos-Rueda (ORCID: https://orcid.org/0000-0002-9961-5544)
- Francisco Jurado (ORCID: https://orcid.org/0000-0001-8122-7415)
- María Lagarde (ORCID: https://orcid.org/0000-0002-7712-6977)
- Andrés Esteban-Cantos (ORCID: https://orcid.org/0000-0002-6318-6207)
- Alejandro de Gea Grela (ORCID: https://orcid.org/0000-0001-9316-8766)
- José Sanz (ORCID: https://orcid.org/0000-0003-3180-184X)
- Patricia Martínez-Martín (ORCID: https://orcid.org/0000-0003-3011-8934)
- Juan Carlos González (ORCID: https://orcid.org/0000-0001-6446-7118)
Institutions
- Hospital Universitario La Paz (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Hospital Clínico San Carlos (ES)
- Research Institute Hospital 12 de Octubre (ES)
- Spanish National Cancer Research Centre (ES)
- Centro de Investigación en Red en Enfermedades Cardiovasculares (ES)
- Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (ES)
- Hospital Universitario Fundación Alcorcón (ES)
- Hospital La Paz Institute for Health Research (ES)
- Hospital Universitario Príncipe de Asturias (ES)
- Centro de Investigación Biomédica en Red (ES)
- Hospital Universitario Infanta Leonor (ES)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1093/cid/ciaf537
- Citations
- 1
- Primary Topic
- HIV-related health complications and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.25
Funders
- Gilead Sciences
- ViiV Healthcare
- Instituto de Salud Carlos III
- European Regional Development Fund
- European Social Fund