A Case of Syndrome of Inappropriate Secretion of Antidiuretic Hormone Induced by Selpercatinib in a Patient With <scp>RET</scp> Fusion Gene‐Positive Non‐Small Cell Lung Cancer
An 80-year-old woman with a lung nodule in the right lower lobe and pleural thickening was diagnosed with lung adenocarcinoma by a surgical lung biopsy. The oncogene panel test showed a positive RET-fusion gene mutation, and selpercatinib was administered as a first-line treatment. She developed severe hyponatremia and was subsequently diagnosed with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Discontinuing selpercatinib and initiating demethyltetracycline gradually improved SIADH. After confirming that sodium levels had returned to normal, we resumed and continued selpercatinib at a reduced dose without a recurrence of SIADH. This case suggests that selpercatinib could cause SIADH as an adverse event.
Authors
- Eisaku Tanaka
- Yuki Ohsumi
- Nobuhiro Okagaki
- Takashi Hajiro
- Yasushige Shingu (ORCID: https://orcid.org/0000-0001-8471-5166)
- Naoya Ikegami (ORCID: https://orcid.org/0000-0002-5956-5968)
- Masakuni Ueyama (ORCID: https://orcid.org/0000-0002-1204-6132)
- Tatsuo Nakagawa (ORCID: https://orcid.org/0000-0002-8461-0564)
- Tsukasa Nakanishi
- Yoshio Taguchi (ORCID: https://orcid.org/0000-0002-9313-2314)
- Satoshi Matsunaga
- Satoshi N. Nakamura
- H Sakamoto
- Yuma Tanaka (ORCID: https://orcid.org/0000-0002-5731-3062)
- Seishu Hashimoto (ORCID: https://orcid.org/0000-0002-1151-4854)
- Yusuke Kaji
- K Matsumura
- Kodai Miyamoto
Institutions
- Tenri Hospital (JP)
- Kurashiki Central Hospital (JP)
- Kobe City Medical Center West Hospital (JP)
Publication Details
- Journal
- Respirology Case Reports
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1002/rcr2.70352
- Citations
- 1
- Primary Topic
- Electrolyte and hormonal disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.52