Dehalogenation hydrolysis of CF ₂ Br ₂ enables four-component aminocarbonylation <i>via</i> photocatalytic radical-polar crossover

Amidocarbonylation represents a pivotal strategy for the construction of amide derivatives; however, achieving an efficient four-component catalytic variant remains particularly challenging. In this study, we successfully developed a four-component aminocarbonylation reaction enabled by the photocatalytic dehalogenation hydrolysis of CF₂Br₂. This methodology exhibits broad substrate scope, accommodating various amines such as diarylamines, arylamines, N-heterocycles, and heterocyclic amines. The synthetic utility of this approach was further highlighted through the preparation of several pharmaceutically relevant compounds and scale-up reaction.