Ononin, a Natural Isoflavone Glycoside, Alleviates Postoperative Cognitive Dysfunction in Aged Mice by Regulating Neuroinflammation and Oxidative Stress
Our findings provide evidence that ononin may ameliorate anesthesia/surgery-induced cognitive deficits through its anti-inflammatory and antioxidant effects, which could be a novel preventive strategy for POCD.
Authors
- Qingbo Yu
- Cansheng Gong (ORCID: https://orcid.org/0000-0003-3915-7593)
- Qilin Liu (ORCID: https://orcid.org/0000-0002-1281-3733)
- Jingyan Lin (ORCID: https://orcid.org/0000-0001-6706-0751)
- Ming Li (ORCID: https://orcid.org/0000-0002-0904-6799)
- Min Zhu (ORCID: https://orcid.org/0000-0002-8892-259X)
- Simin Yang (ORCID: https://orcid.org/0009-0006-0562-8835)
- Qingmei Peng
Institutions
- Fujian Medical University (CN)
- Suizhou Central Hospital (CN)
- Affiliated Hospital of North Sichuan Medical College (CN)
- Fujian Provincial Hospital (CN)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1002/brb3.70952
- Citations
- 3
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.64
Funders
- Natural Science Foundation of Fujian Province