Nickel(II) Bromide Catalyzed Multicomponent Cyclization to Access 4‐Substituted 2‐Iminothiazolines
A method is reported which allows for a three‐component cyclization of sulfoxonium ylides, aryl isothiocyanates, and amines to yield 2‐iminothiazolines. The method overcomes the limitation from the scope‐of‐substrate perspective. Success relies on the use of nickel(II) bromide, presumably acting as a Lewis acid catalyst. Investigation of substrate scopes reveals the compatibility of an array of useful functionalities.
Authors
- Khoa Hien Nguyen
- Tung Thanh Nguyen (ORCID: https://orcid.org/0000-0002-0912-9981)
- Han N. Tran
- Thuy T. Ca
- Vu Huynh Luu (ORCID: https://orcid.org/0009-0004-1738-620X)
- Kien Q. Truong
- Ha Hoang Trinh
Institutions
- Vietnam National University Ho Chi Minh City (VN)
- University of Medicine and Pharmacy at Ho Chi Minh City (VN)
- Hong Bang International University (VN)
- Ho Chi Minh City University of Technology (VN)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1002/ejoc.202500830
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00