Immune system indicators in patients with community-acquired pneumonia and gastroesophageal reflux disease

Objective: to investigate the immune status of patients with community-acquired pneumonia (CAP) and GERD. Materials and Methods: 136 patients were observed, including 100 patients with САP at an average age of (42.3 ± 2.9) years, including 34 patients with САP combined with GERD NERD (group I), 66 patients with САP without of GERD (group II), 36 patients with GERD without CAP observed on an outpatient basis, Group III. The control group consisted of 34 practically healthy donors. Diagnosis of CAP and GERD was carried out in accordance with the existing recommendations. The examined patients had the state of indicators of cellular and humoral immunity and phagocytic activity of monocytes in the dynamics of treatment. Results: patients with CAP combined with GERD and dyspepsia symptoms have a higher level of systemic inflammation than patients with CAP without GERD. The course of CAP combined with GERD is accompanied by secondary immune deficiency due to cellular and humoral immunity, with an imbalance in the phagocytic activity of monocytes. Laboratory signs of systemic inflammation and immune disorders are not fully resolved during the clinical recovery of patients. Conclusions: the identified changes create the preconditions for a personalized approach to the treatment of such patients, with the possible addition of drugs with anti-inflammatory and immunocorrective effects to reduce the likelihood of early and late complications of both comorbid diseases.