The S1P/S1P1 Signaling Axis Plays Regulatory Functions in the Crosstalk Between Brain-Metastasizing Melanoma Cells and Microglia
S1P1 contributes to the immunosuppressive phenotype of microglia. Inhibiting the S1P/S1P1 axis impairs viability and crosstalk between melanoma cells and tumor-activated microglia, offering a potential therapeutic strategy for melanoma brain metastases.
Authors
- Orit Sagi‐Assif (ORCID: https://orcid.org/0000-0001-8235-888X)
- Isaac P. Witz (ORCID: https://orcid.org/0000-0002-0341-4343)
- Sivan Izraely
- Shlomit Ben‐Menachem
- Orit Adir (ORCID: https://orcid.org/0000-0003-0918-6262)
Institutions
- Tel Aviv University (IL)
- Hebrew University of Jerusalem (IL)
Publication Details
- Journal
- Cancers
- Published
- 2025-09-29
- DOI
- https://doi.org/10.3390/cancers17193175
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00