AI-Enhanced Deep Learning Framework for Pulmonary Embolism Detection in CT Angiography

Pulmonary embolism (PE) on CT pulmonary angiography (CTPA) demands rapid, accurate assessment, yet small, low-contrast clots in distal arteries remain challenging. We benchmarked ten fully convolutional network (FCN) backbones and introduced Consensus Intersection-Optimized Fusion (CIOF)-a K-of-M, pixel-wise mask fusion with the voting threshold <i>K</i>* selected on training patients to maximize IoU. Using the FUMPE cohort (35 patients; 12,034 slices) with patient-based random splits (18 train, 17 test), we trained five FCN architectures (each with Adam and SGDM) and evaluated segmentation with IoU, Dice, FNR/FPR, and latency. CIOF achieved the best overall performance (mean IoU 0.569; mean Dice 0.691; FNR 0.262), albeit with a higher runtime (~63.7 s per case) because all ten models are executed and fused; the strongest single backbone was Inception-ResNetV2 + SGDM (IoU 0.530; Dice 0.648). Stratified by embolization ratio, CIOF remained superior across <10^-4, 10^-4-10^-3, and >10^-3 clot burdens, with mean IoU/Dice = 0.238/0.328, 0.566/0.698, and 0.739/0.846, respectively-demonstrating gains for tiny, subsegmental emboli. These results position CIOF as an accuracy-oriented, interpretable ensemble for offline or second-reader use, while faster single backbones remain candidates for time-critical triage.