Induced pluripotent stem cell–derived neural progenitor cells coculturing promotes mice cortical astrocytes antiapoptosis via nuclear factor erythroid 2-related factor 2/heme oxygenase-1 axis in vitro
Our findings demonstrate that iPSC-NPCs protect astrocytes from hemin toxicity via the Nrf2/HO-1 pathway, suggesting a novel therapeutic strategy for ICH-induced oxidative injury.
Authors
- Liuguan Bian (ORCID: https://orcid.org/0000-0003-3436-9503)
- Dong Lin (ORCID: https://orcid.org/0000-0002-6098-0632)
- Xiaohong Chen (ORCID: https://orcid.org/0000-0002-9797-8384)
- Canxin Xu (ORCID: https://orcid.org/0000-0002-5153-2424)
- Zhihong Zhong (ORCID: https://orcid.org/0009-0008-9979-8695)
Institutions
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
Publication Details
- Journal
- Neuroreport
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1097/wnr.0000000000002219
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00