Combined dosage form based on film and gel: technological research, search for ways of use

Introduction. The optimal solution for effective wound treatment is the creation of minimally invasive dosage forms that combine prolonged delivery of drugs and high adhesion to the site of application. The creation of a combined dosage form in the form of a film with a gel applied to it allows to increase the duration of the agent's presence on the affected area, providing a stable effect of the active component on cells and tissues. Research objective. to create a combined dosage form in the form of a film with an applied mucoadhesive gel containing an antibacterial and wound-healing component, respectively. Material and methods. Film samples were prepared on the basis of gelatin, samples based on MC, Na-CMC, Na-alginate, carbopol 940 were obtained as mucoadhesive gels. In order to provide antibacterial action, the polyvalent bacteriophage Sextaphag was introduced into the composition of the films and gels. L-arginine was added to the dosage form as a reparation stimulator. Results. Application of the gel increases the film thickness, reduces the strength characteristics, but significantly increases the extensibility of the material. The mucoadhesiveness indices are significantly improved when using gels based on carbopol. The moisture absorption and vapor permeability indices have satisfactory values, which indicate the maintenance of a favorable environment for wound healing. An experiment on laboratory animals showed an increase in the wound defect regeneration index when using the developed composition compared to the traditional product (Levomekol). Conclusion. The developed combined dosage form has the necessary characteristics for effective wound treatment. This combination provides increased fixation on the wound surface and a prolonged therapeutic effect. The presence of a bacteriophage in the composition of the developed product provides reliable protection against infections.