Melatonin and Virus induced Oncogenic Factors

Melatonin is a hormone that has shown potential in alleviating side effects such as inflammation, oxidative stress, and damage to non-neoplasmic tissues. It protects against chemotherapy-induced ovarian damage and mitigates cognitive impairments linked to cancer treatments. Melatonin enhances immune system activity, particularly in modulating immune cells like natural killer (NK) cells and macrophages. This contributes to its ability to control tumor growth and metastasis. Recent research has explored the role of melatonin in cancer therapy, revealing its potential as a multifaceted agent in oncology. Melatonin exhibits several properties that make it promising in the treatment and management of tumors. Anti-Tumor and Anti-Proliferative Effects: Melatonin directly inhibits cancer cell proliferation by modulating signaling pathways such as p53, NF-κB, and Wnt/β-catenin. It can suppress angiogenesis and metastasis by interfering with pathways like epithelialmesenchymal transition (EMT) and reducing the invasive potential of cancer cells. Studies show melatonin enhances the efficacy of chemotherapy and radiotherapy. In this chapter it discusses correlation between melatonin treatment in tumor cells to treatments. It evaluates action has potential to decrease viral induced tumor incidence while protecting healthy cells from the side effects of these therapies