Brain Frailty and Functional Outcomes After Thrombolysis for Acute Ischemic Stroke
In this cohort study of patients with AIS treated with intravenous thrombolysis, brain frailty markers-particularly white matter changes, cortical atrophy, and total brain frailty-were associated with worse outcomes. Consideration of these neuroimaging markers may better inform clinicians and patients about treatment expectations from thrombolytic therapy.
Authors
- Faysal Benali
- Houman Khosravani (ORCID: https://orcid.org/0000-0002-4059-9420)
- Aleksandra Pikula (ORCID: https://orcid.org/0000-0001-7077-0148)
- Aleksander Tkach (ORCID: https://orcid.org/0009-0009-4063-4431)
- Brian H Buck (ORCID: https://orcid.org/0000-0002-7984-6062)
- Aravind Ganesh (ORCID: https://orcid.org/0000-0001-5520-2070)
- Spencer P. Loewen
- Mohammed Almekhlafi (ORCID: https://orcid.org/0000-0001-9550-8197)
- Dar Dowlatshahi (ORCID: https://orcid.org/0000-0003-1379-3612)
- Gary Hunter (ORCID: https://orcid.org/0000-0003-2033-8001)
- William Betzner (ORCID: https://orcid.org/0000-0002-9071-0705)
- Michel Christopher Frank Shamy (ORCID: https://orcid.org/0000-0002-0085-6816)
- Federico Carpani (ORCID: https://orcid.org/0000-0003-4696-5994)
- Mahesh Kate (ORCID: https://orcid.org/0000-0003-4794-2882)
- Rick Swartz (ORCID: https://orcid.org/0000-0001-6571-5531)
- Nishita Singh (ORCID: https://orcid.org/0000-0003-3647-0904)
- Fouzi Bala (ORCID: https://orcid.org/0000-0001-6748-2081)
- Thalia Shoshana Field (ORCID: https://orcid.org/0000-0002-1176-0633)
- Luciana Catanese (ORCID: https://orcid.org/0000-0002-8696-5211)
- Kaden Lam (ORCID: https://orcid.org/0000-0002-6774-1167)
- Bijoy K. Menon (ORCID: https://orcid.org/0000-0002-3466-496X)
- Tolulope T. Sajobi (ORCID: https://orcid.org/0000-0002-5696-5552)
- Ibrahim Alhabli (ORCID: https://orcid.org/0000-0002-6293-6934)
Institutions
- Université de Tours (FR)
- Sunnybrook Health Science Centre (CA)
- University of British Columbia (CA)
- University of Ottawa (CA)
- University of Alberta (CA)
- University of Calgary (CA)
- University of Toronto (CA)
- Toronto Western Hospital (CA)
- Ottawa Hospital (CA)
- Kelowna General Hospital (CA)
- Health Sciences Centre (CA)
- Population Health Research Institute (CA)
- University of Saskatchewan (CA)
- O'Brien Institute (AU)
- Centre Hospitalier Universitaire de Tours (FR)
- AZ Sint-Blasius (BE)
- Ottawa Hospital Research Institute (CA)
- University of Manitoba (CA)
- McMaster University (CA)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.34941
- Citations
- 6
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 8.13