Exogenous chemical exposures and metabolic disruptions in hyperuricemia: a multi-omics mediation study
In summary, hyperuricemia is related to the interplay of environmental exposures and individual genetic susceptibility, with metabolic dysregulation serving as a crucial mediating link. These findings offer novel insights into the potential health risks associated with exogenous chemical exposures.
Authors
- Guowang Xu (ORCID: https://orcid.org/0000-0003-4298-3554)
- Di Yu (ORCID: https://orcid.org/0000-0003-0801-1225)
- Qi Li
- Xinyu Liu (ORCID: https://orcid.org/0000-0002-0564-7167)
- Weimin Ye (ORCID: https://orcid.org/0000-0002-6859-4648)
- Mengyao Wang (ORCID: https://orcid.org/0000-0002-9085-3749)
- Shanshan Du (ORCID: https://orcid.org/0000-0002-0485-9029)
- Lvyun Sun (ORCID: https://orcid.org/0009-0005-9148-5369)
- Yang Ouyang (ORCID: https://orcid.org/0000-0002-6652-1779)
- Xiaolin Wang
Institutions
- Fujian Medical University (CN)
- Dalian Institute of Chemical Physics (CN)
Publication Details
- Journal
- Environment International
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1016/j.envint.2025.109832
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 0.00