D3-GPC2–Directed CAR T Cells Are Safe and Efficacious in Preclinical Models of Neuroblastoma and Small Cell Lung Cancer
These data validate GPC2 as a bona fide CAR T-cell target in neuroblastoma and other cancers. The safety and preliminary efficacy of GPC2 CAR T cells are being tested in a first-in-human phase I clinical trial for children with relapsed/refractory neuroblastoma (NCT05650749).
Authors
- David Groff (ORCID: https://orcid.org/0000-0001-6897-2656)
- John M. Maris (ORCID: https://orcid.org/0000-0002-8088-7929)
- Enrico Radaelli (ORCID: https://orcid.org/0000-0002-2885-0221)
- Kristopher R. Bosse (ORCID: https://orcid.org/0000-0002-1424-2858)
- Jennifer Pogoriler (ORCID: https://orcid.org/0000-0001-9366-4401)
- Adam J. Wolpaw (ORCID: https://orcid.org/0000-0002-1373-7648)
- Timothy T. Spear (ORCID: https://orcid.org/0000-0001-7740-5119)
- David M. Barrett (ORCID: https://orcid.org/0000-0002-8302-3114)
- Daniel Martínez (ORCID: https://orcid.org/0000-0002-4723-9989)
- Whitney L. Gladney (ORCID: https://orcid.org/0009-0000-1977-8566)
- Brendan McIntyre (ORCID: https://orcid.org/0000-0002-6473-5140)
- Bruce Pawel (ORCID: https://orcid.org/0000-0001-7678-5324)
- Ted J. Hofmann (ORCID: https://orcid.org/0000-0002-1944-0618)
- Anna Maria Giudice (ORCID: https://orcid.org/0000-0002-3296-175X)
- Sydney L. Roth (ORCID: https://orcid.org/0009-0007-2442-6515)
- Guillem Pascual‐Pasto (ORCID: https://orcid.org/0000-0001-8537-261X)
- Stephan A. Grupp (ORCID: https://orcid.org/0000-0001-8030-7595)
- Charles‐Antoine Assenmacher (ORCID: https://orcid.org/0000-0003-0073-2730)
- Stephanie Matlaga (ORCID: https://orcid.org/0009-0005-7463-6022)
- Vincent Zecchino (ORCID: https://orcid.org/0009-0004-3257-8226)
Institutions
- Children's Hospital of Philadelphia (US)
- Children's Hospital of Los Angeles (US)
- Loyola University Chicago (US)
- Aadi (United States) (US)
- Gilead Sciences (United States) (US)
- Kite (United States) (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-0089
- Citations
- 2
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 2.09