At-line determination of the enantiomeric excess in multi-component chiral samples using Raman optical activity (ROA)

According to our best knowledge, our work is a first example of successful in-flow and in situ ROA evaluation of chiral purity in chiral mixtures. Our direct approach does not require extensive sample preparation, preliminary separation of enantiomers or derivatization. In the long-term, our solution paves the way toward operando (in-line) ROA, enabling real-time monitoring of chirality in reaction mixtures.