AGS-v PLUS, a Mosquito Salivary Peptide Vaccine, Modulates the Response to Aedes Mosquito Bites in Humans
These findings demonstrate that targeting the host response to mosquito saliva via vaccination can reprogram the skin's immune response to mosquito bites, supporting a novel and broadly applicable pan-viral strategy to mitigate the impact of arboviral diseases.
Authors
- Megan E. Cole (ORCID: https://orcid.org/0000-0002-5154-5786)
- Matthew B. Laurens (ORCID: https://orcid.org/0000-0003-3874-581X)
- Mara Short (ORCID: https://orcid.org/0000-0002-9756-865X)
- Lucy F. Stead (ORCID: https://orcid.org/0000-0002-9550-4150)
- Clive S. McKimmie (ORCID: https://orcid.org/0000-0002-7694-9509)
- Fabiano Oliveira (ORCID: https://orcid.org/0000-0002-7924-8038)
- Olga Pleguezuelos (ORCID: https://orcid.org/0000-0002-7099-5002)
- Jesus Gilberto Valenzuela (ORCID: https://orcid.org/0000-0002-5589-9450)
- Aiyana Ponce
- DeAnna Friedman-Klabanoff (ORCID: https://orcid.org/0000-0003-0373-4643)
- Siân E. Jossi (ORCID: https://orcid.org/0000-0003-0447-5030)
- Ian Carr (ORCID: https://orcid.org/0000-0001-9544-1068)
- Joshua R. Lacsina (ORCID: https://orcid.org/0000-0002-9956-8039)
- Liam Barningham (ORCID: https://orcid.org/0009-0008-3851-680X)
- Claudio Meneses
Institutions
- University of Maryland, Baltimore (US)
- National Institutes of Health (US)
- University of Arizona (US)
- St James's University Hospital (GB)
- Bioscience Research (US)
- National Institute of Allergy and Infectious Diseases (US)
- Hull York Medical School (GB)
Publication Details
- Journal
- Vaccines
- Published
- 2025-09-30
- DOI
- https://doi.org/10.3390/vaccines13101026
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00