Prediction of Diabetic Neuropathy in Patients with Type 2 Diabetes Mellitus by Using Monocyte to High-Density Lipoprotein Cholesterol Ratio

Background: Diabetic peripheral neuropathy (DPN) is one of the most common and debilitating microvascular complications of type 2 diabetes mellitus (T2DM) with complex and multifactorial pathogenesis involving chronic hyperglycemia, oxidative stress, and sustained low-grade inflammation. Traditional biochemical markers often fall short in early identification of DPN. Emerging evidences suggest that inflammatory markers such as the monocyte-to-high-density lipoprotein cholesterol ratio (MHR) may serve as a novel biomarker reflecting systemic inflammation and oxidative stress.