Gadd45B Deficiency Drives Radio-Resistance in BRAFV600E-Mutated Differentiated Thyroid Cancer by Disrupting Iodine Metabolic Genes
Gadd45B plays a pivotal role in regulating the differentiation status and RAI sensitivity of BRAF<sup>V600E</sup>-mutated thyroid cancer. These findings identify Gadd45B as a promising therapeutic target for restoring RAI responsiveness in RAIR-DTC patients.
Authors
- A. Kassardjian (ORCID: https://orcid.org/0000-0003-3588-1648)
- Shan Jiang (ORCID: https://orcid.org/0000-0002-1545-2152)
- Zhaobo Wang (ORCID: https://orcid.org/0000-0002-9011-6220)
- Tengchuang Ma (ORCID: https://orcid.org/0000-0002-0352-4526)
- Zhiwen Hong
- Yali Cui (ORCID: https://orcid.org/0000-0001-8397-4588)
- Qianjiang Wu
- Xinghua Wang (ORCID: https://orcid.org/0000-0002-2521-9944)
- Xue Guan
- A Rouhan
Institutions
- City Of Hope National Medical Center (US)
- Harbin Medical University (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Cancers
- Published
- 2025-09-30
- DOI
- https://doi.org/10.3390/cancers17193201
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00