Organ Preservation via Immunotherapy-Based Total Neoadjuvant Therapy in Early Low Rectal Cancer (TORCH-E): A Multicenter, Open-label, Single-Arm, Phase II Study
As an exploratory trial, TORCH-E demonstrated a promising iTNT approach achieving a high CR rate, enabling OP through WW and selective LE in early low rectal cancer, warranting subsequent randomized validation.
Authors
- Menglong Zhou (ORCID: https://orcid.org/0000-0002-8130-5812)
- Yikuan Chen (ORCID: https://orcid.org/0000-0002-0219-4756)
- Xinxiang Li (ORCID: https://orcid.org/0000-0002-2354-4735)
- Jinluan Li (ORCID: https://orcid.org/0000-0002-3533-898X)
- Di Zhou (ORCID: https://orcid.org/0000-0001-9714-2993)
- Wenchao Gu (ORCID: https://orcid.org/0000-0002-1505-9887)
- Yajie Chen (ORCID: https://orcid.org/0000-0001-8850-1886)
- Yan Wang (ORCID: https://orcid.org/0000-0001-8750-9341)
- Juefeng Wan (ORCID: https://orcid.org/0000-0001-5361-1663)
- Ruiyan Wu (ORCID: https://orcid.org/0000-0003-2720-5869)
- Hui Zhang (ORCID: https://orcid.org/0000-0001-8803-2696)
- Yaqi Wang (ORCID: https://orcid.org/0000-0002-8003-6251)
- Zhen Zhang (ORCID: https://orcid.org/0000-0001-7825-2679)
- Yiqun Sun (ORCID: https://orcid.org/0000-0002-3375-3012)
- Sanjun Cai (ORCID: https://orcid.org/0000-0003-4134-0274)
- Lijun Shen (ORCID: https://orcid.org/0000-0001-9459-8338)
- Lei Wang (ORCID: https://orcid.org/0000-0002-1827-5470)
- Fan Xia (ORCID: https://orcid.org/0000-0001-8185-8663)
- Shujuan Zhou (ORCID: https://orcid.org/0000-0002-2479-9246)
- Wang Yang (ORCID: https://orcid.org/0000-0001-9115-7932)
- Dakui Luo (ORCID: https://orcid.org/0009-0005-9767-2296)
- Fangqi Liu (ORCID: https://orcid.org/0000-0002-3881-5825)
- Peng Lian (ORCID: https://orcid.org/0009-0000-2529-8710)
- Junjie Peng (ORCID: https://orcid.org/0000-0002-3532-8431)
Institutions
- Fujian Medical University (CN)
- Shanghai Medical College of Fudan University (CN)
- Shanghai University of Engineering Science (CN)
- Chiba University (JP)
- Fudan University (CN)
- Renji Hospital (CN)
- Fudan University Shanghai Cancer Center (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
- Jiangmen Central Hospital (CN)
- Fujian Provincial Cancer Hospital (CN)
- Shanghai Clinical Research Center (CN)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-0975
- Citations
- 1
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.05