Response of murine fibroblasts or human keratinocytes to micro- and nano-scale titanium particles: the permeability of particles across keratinocytes' monolayers
Altogether, nano-scale titanium particles decreased the viability of fibroblasts although a significant viability of keratinocytes has been detected by standard cell culture assays. However, nano-scale titanium particles were found into keratinocytes and even trespassed the cells' layers that could reach other cells and blood vessels in an in vivo scenario. Thus, toxicity of titanium particles depends on their particle size, exposure time, content, and interaction with the surrounding media.
Authors
- Hassan Bousbaa (ORCID: https://orcid.org/0000-0002-4006-5779)
- Júlio C. M. Souza (ORCID: https://orcid.org/0000-0001-7999-4009)
- Bruno Sarmento (ORCID: https://orcid.org/0000-0001-5763-7553)
- Redouane Messous
- Andreia Almeida (ORCID: https://orcid.org/0000-0001-6186-8696)
- Rui Pedro Moura
- Catarina Pacheco (ORCID: https://orcid.org/0000-0002-9148-8915)
- Patrícia M. A. Silva (ORCID: https://orcid.org/0000-0002-0694-7321)
Institutions
- Universidade do Porto (PT)
- Cooperativa de Ensino Superior Politécnico e Universitário (PT)
- i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto (PT)
- University of Minho (PT)
Publication Details
- Journal
- Clinical Oral Investigations
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1007/s00784-025-06492-1
- Primary Topic
- Nanoparticles: synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação para a Ciência e a Tecnologia