Global, regional, and national burden of digestive congenital anomalies from 1990–2021

We analyzed global trends in the prevalence, mortality, and DALYs of digestive congenital anomalies (DCAs) from 1990 to 2021 using data from the Global Burden of Disease Study 2021. Our findings reveal that although the global burden of DCAs has declined, significant disparities persist, particularly in low- and middle-SDI regions. Frontier analysis emphasized substantial improvement potential in these regions. These results underscore the urgent need for enhanced screening programs, healthcare resources, and targeted interventions in low-SDI regions to further reduce the burden of DCAs and achieve equitable healthcare outcomes.

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Publication Details

Journal
Pediatric Research
Published
2025-09-30
DOI
https://doi.org/10.1038/s41390-025-04442-x
Primary Topic
Esophageal and GI Pathology
Type
article
Field-Weighted Citation Impact
0.00

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article

Global, regional, and national burden of digestive congenital anomalies from 1990–2021

Dengming Lai, Lei Cai, Qibin Geng, Henning Gong et al.
Pediatric Research
Esophageal and GI Pathology
article

Global, regional, and national burden of digestive congenital anomalies from 1990–2021

Dengming Lai, Lei Cai, Qibin Geng, Henning Gong, Jinfa Tou
article en

Abstract

We analyzed global trends in the prevalence, mortality, and DALYs of digestive congenital anomalies (DCAs) from 1990 to 2021 using data from the Global Burden of Disease Study 2021. Our findings reveal that although the global burden of DCAs has declined, significant disparities persist, particularly in low- and middle-SDI regions. Frontier analysis emphasized substantial improvement potential in these regions. These results underscore the urgent need for enhanced screening programs, healthcare resources, and targeted interventions in low-SDI regions to further reduce the burden of DCAs and achieve equitable healthcare outcomes.

Pediatric Research
Children's Hospital of Zhejiang University (CN), Zhejiang University (CN)
National Natural Science Foundation of China, Zhejiang University, Fundamental Research Funds for the Central Universities, Natural Science Foundation of Zhejiang Province
Openalex Percentile: Top 57%
Esophageal and GI Pathology
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