Molecular epidemiology of panton valentine leukocidin-producing Staphylococcus aureus infections, Djibouti, 2018–2023
Between 2018 and 2023, a genomic study was conducted in a military camp in Djibouti to investigate the molecular epidemiology of Panton-Valentine Leukocidin-producing Staphylococcus aureus. Among 43 isolates, Sequence Type 152 was predominant (72%), mainly associated with spa types t355 and t4235. Core-genome Multi-Locus Sequence Typing revealed two concurrent transmission dynamics: localized inter-human outbreaks and repeated introductions from external sources. Comparative genomics with other African Sequence Type 152 isolates showed similar levels of diversity, suggesting a widespread continental dissemination. These findings highlight the importance of genomic surveillance to better understand and control the spread of this virulent lineage in Africa.
Authors
- Hervé Jacquier (ORCID: https://orcid.org/0000-0002-6323-5910)
- Paul‐Louis Woerther (ORCID: https://orcid.org/0000-0002-6957-9482)
- Virginie Courbin
- Maxime Danjean
- Christophe Rodriguez (ORCID: https://orcid.org/0000-0002-9817-5006)
- A. M.‐H. Ho
- Aurore Bousquet
Institutions
- Inserm (FR)
- Université Paris-Est Créteil (FR)
- Centre Hospitalier Universitaire Henri-Mondor (FR)
- Hôpital d'Instruction des Armées Bégin (FR)
- Hôpitaux Universitaires Henri-Mondor (FR)
- Institut Mondor de Recherche Biomédicale (FR)
- DYNAMYC MYCOLOGY
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1371/journal.pntd.0013544
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.00