Profiling Human Papillomavirus Lineage-Specific Capsid Antigenicity With Geographically Diverse Natural Infection Antibodies

Human papillomavirus variants are classified into lineages based on their whole genome sequence, but the impact of lineage variation on the structure or function of encoded proteins is unclear. We used a global panel of lineage-specific natural infection sera to assess antibody-binding specificity for lineage-specific L1L2 antigens, and we used these data to create relational antigenic maps. Merging these data with neutralizing antibody data demonstrated similar spatial geometry and revealed dependency on a limited number of amino residues on the capsid surface. These data inform the degree of lineage specificity within the natural infection humoral immune response to oncogenic human papillomaviruses.

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Publication Details

Journal
The Journal of Infectious Diseases
Published
2025-09-26
DOI
https://doi.org/10.1093/infdis/jiaf502
Primary Topic
Cervical Cancer and HPV Research
Type
article
Field-Weighted Citation Impact
0.00

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article

Profiling Human Papillomavirus Lineage-Specific Capsid Antigenicity With Geographically Diverse Natural Infection Antibodies

Kavita Panwar, Simon Beddows, Lisa Mirabello, Mónica S. Sierra et al.
The Journal of Infectious Diseases
Cervical Cancer and HPV Research
article

Profiling Human Papillomavirus Lineage-Specific Capsid Antigenicity With Geographically Diverse Natural Infection Antibodies

Kavita Panwar, Simon Beddows, Lisa Mirabello, Mónica S. Sierra, Kazutomo Yokoya, Vanessa Tenet, John Schussler, Gary M. Clifford, John T. Schiller, Rolando Herrero, Shayane Martins Rodrigues Gomes
article en

Abstract

Human papillomavirus variants are classified into lineages based on their whole genome sequence, but the impact of lineage variation on the structure or function of encoded proteins is unclear. We used a global panel of lineage-specific natural infection sera to assess antibody-binding specificity for lineage-specific L1L2 antigens, and we used these data to create relational antigenic maps. Merging these data with neutralizing antibody data demonstrated similar spatial geometry and revealed dependency on a limited number of amino residues on the capsid surface. These data inform the degree of lineage specificity within the natural infection humoral immune response to oncogenic human papillomaviruses.

The Journal of Infectious DiseasesVol. 233(1)
Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud (CR), Information Management Services (US), National Cancer Institute (US), Cancer Genetics (United States) (US), Center for Cancer Research (US), Associated Management Services (United States) (US), Centre international de recherche sur le cancer (FR), UK Health Security Agency (GB), Division of Cancer Epidemiology and Genetics
GlaxoSmithKline, Austrian Centre of Industrial Biotechnology, National Institutes of Health, National Cancer Institute, Office of Research on Women's Health
Openalex Percentile: Top 64%
Cervical Cancer and HPV Research
DOIOpen Access PDFOpenAlex
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