Primary endocrine therapy versus surgery plus endocrine therapy for early-stage breast cancer in older women without frailty: a cost-effectiveness and value of implementation analysis
Surgery with adjuvant ET is a clinically effective and cost-effective strategy compared with PET for older women with ER + operable early-stage breast cancer. Strengthening adherence to national guidelines will improve population health outcomes and healthcare resource use. Future economic evaluations should focus on the value of management strategies for older patients unfit for surgery due to frailty or comorbidities.
Authors
- Kwok‐Leung Cheung (ORCID: https://orcid.org/0000-0003-2973-0755)
- Douglas Steinke (ORCID: https://orcid.org/0000-0001-8917-2674)
- Li‐Chia Chen (ORCID: https://orcid.org/0000-0002-6158-6645)
- Sean P. Gavan (ORCID: https://orcid.org/0000-0003-3659-056X)
- Yubo Wang (ORCID: https://orcid.org/0000-0002-2686-8946)
Institutions
- University of Nottingham (GB)
- Xinjiang Medical University (CN)
- Royal Derby Hospital (GB)
- Manchester Academic Health Science Centre (GB)
- First Affiliated Hospital of Xinjiang Medical University (CN)
- University of Manchester (GB)
Publication Details
- Journal
- Health Economics Review
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1186/s13561-025-00668-x
- Primary Topic
- Health Systems, Economic Evaluations, Quality of Life
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Manchester
- China Scholarship Council