Subcortical volume alteration and correlation with social function under chlorpromazine versus clozapine treatment in schizophrenia
Our results suggest that distinct neuroanatomical differences may be associated with various antipsychotic treatments in schizophrenia. These subcortical alterations may reflect differential pharmacological effects, and thalamic volume could represent a potential neuroimaging marker related to social function.
Authors
- Xiangrong Zhang (ORCID: https://orcid.org/0000-0002-2737-2168)
- Xiao Bin Zhang (ORCID: https://orcid.org/0000-0002-6204-3685)
- Xiaowei Tang (ORCID: https://orcid.org/0000-0001-6064-0526)
- Ju Gao (ORCID: https://orcid.org/0009-0003-4765-4554)
- Qianqian Jiang (ORCID: https://orcid.org/0000-0002-9877-6303)
- Jieting Jia (ORCID: https://orcid.org/0000-0002-2036-3672)
- Jin Li (ORCID: https://orcid.org/0000-0002-2498-2657)
- Ping Yang (ORCID: https://orcid.org/0000-0002-4397-5567)
Institutions
- Soochow University (CN)
- Suzhou Guangji Hospital (CN)
- Nanjing Brain Hospital (CN)
- Northern Jiangsu People's Hospital (CN)
- Shanghai Changning Mental Health Center (CN)
- East China Normal University (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- BMC Psychiatry
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1186/s12888-025-07309-x
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Government of Jiangsu Province