Safety and Efficacy of Cisplatin and Doxorubicin Pressurized Intraperitoneal Aerosolized Chemotherapy (PIPAC) in Patients with Ovarian Cancer with Peritoneal Metastases: A Multicenter US Phase I Trial
PIPAC-CD is feasible, safe, and well tolerated at academic US centers. OS and PFS were limited in patients with heavily pretreated ovarian carcinoma who underwent PIPAC-CD. Future trials should focus on optimizing PIPAC drug combinations and determining optimal patient selection criteria for ovarian cancer.
Authors
- Daphne Stewart (ORCID: https://orcid.org/0000-0001-9845-8375)
- Richard L. Whelan (ORCID: https://orcid.org/0000-0002-9707-4967)
- Alexander Jung (ORCID: https://orcid.org/0000-0001-7538-0990)
- Raechelle Tinsley (ORCID: https://orcid.org/0009-0000-7076-4266)
- Timothy W. Synold (ORCID: https://orcid.org/0000-0002-4075-2544)
- Wenge Wang (ORCID: https://orcid.org/0000-0001-9509-6735)
- Brad J. Nakamura (ORCID: https://orcid.org/0000-0001-8246-3479)
- Amit Merchea (ORCID: https://orcid.org/0000-0001-7880-7080)
- Melissa Eng
- Jeannine Villella (ORCID: https://orcid.org/0000-0001-7156-352X)
- Susan E. Yost (ORCID: https://orcid.org/0000-0002-9422-0316)
- Thanh H. Dellinger (ORCID: https://orcid.org/0000-0003-1855-1989)
- Joshua Cohen (ORCID: https://orcid.org/0000-0001-8743-2233)
- Nora Ruel (ORCID: https://orcid.org/0000-0002-4591-3618)
- Yanghee Woo (ORCID: https://orcid.org/0000-0002-6676-0593)
- Danielle K. DePeralta (ORCID: https://orcid.org/0000-0001-5990-0124)
- Mustafa Raoof (ORCID: https://orcid.org/0000-0003-4710-2226)
- Paul Frankel (ORCID: https://orcid.org/0000-0003-2231-6121)
- Sarah Cole (ORCID: https://orcid.org/0000-0002-9979-7093)
- Rosemary Senguttuvan
- Sue Chang
Institutions
- City Of Hope National Medical Center (US)
- Northwell Health (US)
- Jacksonville College (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Annals of Surgical Oncology
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1245/s10434-025-18432-0
- Citations
- 2
- Primary Topic
- Intraperitoneal and Appendiceal Malignancies
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- National Institutes of Health
- National Cancer Institute