Detection of PIK3CA Mutations in Anal Dysplasia
PIK3CA mutations can be detected in anal tissue samples across the spectrum of carcinogenesis with increasing incidence with higher grade of disease. Our results warrant further evaluation of PIK3CA mutations as a biomarker for identifying patients with anal dysplasia at highest risk of progression to anal cancer.
Authors
- Evie H. Carchman (ORCID: https://orcid.org/0000-0002-5536-7761)
- Glen Leverson (ORCID: https://orcid.org/0000-0003-2286-3088)
- Corinne Praska (ORCID: https://orcid.org/0000-0002-4937-1377)
- Hillary R. Johnson (ORCID: https://orcid.org/0000-0001-6748-5143)
- Kirsten L. Dennison
- Muhammed Murtaza (ORCID: https://orcid.org/0000-0001-7557-2861)
- Stephanie M. McGregor (ORCID: https://orcid.org/0000-0002-7940-1143)
- Willi Suter
- Elise C. Dietmann (ORCID: https://orcid.org/0009-0001-0771-7501)
Institutions
- University of Wisconsin–Madison (US)
- University of Wisconsin Carbone Cancer Center (US)
- William S. Middleton Memorial Veterans Hospital (US)
Publication Details
- Journal
- Journal of Surgical Research
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1016/j.jss.2025.09.003
- Primary Topic
- Colorectal and Anal Carcinomas
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Cancer Institute