Transmission of bedaquiline-resistant <i>Mycobacterium tuberculosis</i> in KwaZulu-Natal, South Africa
Bedaquiline resistance was common in this cohort of individuals with highly drug-resistant TB. Most bedaquiline-resistant infections were attributable to recent transmission, involving Mtb strains with diverse genetic backgrounds and a variety of causative mutations. The diversity and transmissibility of bedaquiline-resistant Mtb signal a growing public health threat.
Authors
- Yu Lan (ORCID: https://orcid.org/0000-0003-0373-1944)
- Lavania Joseph (ORCID: https://orcid.org/0000-0003-0734-7149)
- Joshua L. Warren (ORCID: https://orcid.org/0000-0002-6274-6970)
- Neel R. Gandhi (ORCID: https://orcid.org/0000-0002-1665-299X)
- Robert W. Sobol (ORCID: https://orcid.org/0000-0001-7385-3563)
- Neha Shah (ORCID: https://orcid.org/0000-0002-9575-9161)
- Kogieleum Naidoo (ORCID: https://orcid.org/0000-0002-8874-6661)
- Tyler S. Brown (ORCID: https://orcid.org/0000-0003-2559-2789)
- Ted Cohen (ORCID: https://orcid.org/0000-0002-8091-7198)
- Fay Willis
- Shaheed Vally Omar (ORCID: https://orcid.org/0000-0001-6983-1636)
- Keeren Lutchminarian (ORCID: https://orcid.org/0000-0001-5198-1994)
- Angela Campbell (ORCID: https://orcid.org/0000-0003-3990-3656)
- Barun Mathema (ORCID: https://orcid.org/0000-0003-2772-479X)
- Linrui Tang (ORCID: https://orcid.org/0000-0003-0144-0019)
- James C.M. Brust
Institutions
- National Health Laboratory Service (ZA)
- Boston University (US)
- Albert Einstein College of Medicine (US)
- Montefiore Medical Center (US)
- Emory University (US)
- Columbia University Irving Medical Center (US)
- Centre for the AIDS Programme of Research in South Africa (ZA)
- Yale University (US)
- Yale New Haven Health System (US)
- National Institute for Occupational Health (ZA)
- Columbia University (US)
Publication Details
- Journal
- American Journal of Respiratory and Critical Care Medicine
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1164/rccm.202506-1489oc
- Citations
- 3
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 4.19