Gain-of-Function Variant in <i>STAT3</i> and Retinal Macular Edema: Insights into the IL-6 R/JAK/ <i>STAT3</i> Pathway in Retinal Pigment Epithelium
The pathogenic STAT3 p.L387R GOF variant enhances inflammatory cytokine production in human primary RPE cells, potentially exacerbating retinal vascular leakage and macular edema. These effects can be mitigated by JAK1/2 inhibition, highlighting a promising therapeutic strategy for retinal inflammation and associated edema.
Authors
- Kasiphak Kaikaew (ORCID: https://orcid.org/0000-0002-1790-1839)
- P. Martin van Hagen (ORCID: https://orcid.org/0000-0003-0854-2368)
- Tom Missotten (ORCID: https://orcid.org/0000-0003-0600-9850)
- Mirthe S. Lourens
- Zijun Zhou (ORCID: https://orcid.org/0009-0001-2119-193X)
- Mirjam E. J. van Velthoven (ORCID: https://orcid.org/0000-0002-5376-4173)
- Narissara Suratannon (ORCID: https://orcid.org/0000-0003-1182-3611)
- Willem A. Dik (ORCID: https://orcid.org/0000-0001-5235-3156)
- Kornvalee Meesilpavikkai (ORCID: https://orcid.org/0000-0002-3502-6345)
- Nattiya Hirankarn (ORCID: https://orcid.org/0000-0003-2224-6856)
- Hanna IJspeert (ORCID: https://orcid.org/0000-0002-7061-5321)
- Suphattra Phakham
- Sigrid M. A. Swagemakers
- Peter J. van der Spek
Institutions
- Chulalongkorn University (TH)
- Erasmus MC (NL)
- Rotterdam Eye Hospital (NL)
- Combined Ophthalmic Research Rotterdam (NL)
Publication Details
- Journal
- Ocular Immunology and Inflammation
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1080/09273948.2025.2551803
- Citations
- 1
- Primary Topic
- Ocular Diseases and Behçet’s Syndrome
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- Chulalongkorn University
- China Scholarship Council
- National Research Council of Thailand
- Stichting Wetenschappelijk Onderzoek Oogziekenhuis