Inotuzumab Ozogamicin Then Blinatumomab for Older Adults With Newly Diagnosed B-Cell ALL: Alliance Study A041703 Cohort 1 Results
Inotuzumab ozogamicin then blinatumomab without maintenance chemotherapy in older patients with untreated, Ph-negative, CD22-positive, B-cell ALL yields a high remission rate and excellent EFS. Given the lack of standard, safe, and effective therapies in this population, the regimen should be considered a standard treatment option.
Authors
- Wendy Stock (ORCID: https://orcid.org/0000-0002-8349-9200)
- Oudom Kour
- Matthew Joseph Wieduwilt (ORCID: https://orcid.org/0000-0002-5414-9228)
- Scott Hall
- James K. Mangan (ORCID: https://orcid.org/0000-0002-7308-3260)
- Alice S. Mims (ORCID: https://orcid.org/0000-0002-8971-2199)
- Kimberley Doucette (ORCID: https://orcid.org/0000-0003-1165-2250)
- Carolin S. Escherich (ORCID: https://orcid.org/0000-0002-1402-3647)
- Jun J. Yang (ORCID: https://orcid.org/0000-0002-0770-9659)
- Kenneth Byrd
- Shira Naomi Dinner (ORCID: https://orcid.org/0000-0002-3635-6741)
- Richard Maury Stone (ORCID: https://orcid.org/0000-0002-7526-2633)
- Giorgia Giordano (ORCID: https://orcid.org/0009-0004-7473-5883)
- Mark Robert Litzow (ORCID: https://orcid.org/0000-0002-9816-6302)
- Rebecca Teske
- Zhenhua Li (ORCID: https://orcid.org/0000-0002-3623-6571)
- Geoffrey L. Uy (ORCID: https://orcid.org/0000-0002-7809-0996)
- Jun Yin (ORCID: https://orcid.org/0000-0003-3242-9664)
- Caner Saygin (ORCID: https://orcid.org/0000-0003-1315-0377)
- Ali W. Bseiso
- Katarzyna Jamieson (ORCID: https://orcid.org/0009-0004-0947-0874)
Institutions
- University of North Carolina at Chapel Hill (US)
- St. Jude Children's Research Hospital (US)
- Georgetown University (US)
- Washington University in St. Louis (US)
- University Hospitals of Cleveland (US)
- University of Chicago (US)
- Mayo Clinic in Arizona (US)
- Alliance Data (United States) (US)
- University of Kansas Medical Center (US)
- University of California San Diego Medical Center (US)
- Wake Forest University (US)
- The Ohio State University (US)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1200/jco-25-00307
- Citations
- 2
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 3.76