Benchmarking standard-of-care and emerging genomic approaches to enhance diagnosis in pediatric acute lymphoblastic leukemia
Integrating these technologies into diagnostic workflows overcomes SoC limitations. OGM and the dMLPA-RNAseq combination emerge as front-line strategies, addressing pALL heterogeneity, streamlining molecular testing, and informing treatment decisions to improve outcomes.
Authors
- Carolina Fuentes
- Eva Barragán (ORCID: https://orcid.org/0000-0001-6735-0038)
- Marta Llop (ORCID: https://orcid.org/0000-0002-0106-7296)
- María Del Cañizo (ORCID: https://orcid.org/0000-0002-8397-1915)
- Esperanza Such (ORCID: https://orcid.org/0000-0001-6892-403X)
- José M. Fernández (ORCID: https://orcid.org/0000-0002-4806-5140)
- António A. Vicente (ORCID: https://orcid.org/0000-0003-3593-8878)
- José Vicente Gil (ORCID: https://orcid.org/0000-0003-2097-4796)
- Carolina López-Benet
- Rafael Andreu (ORCID: https://orcid.org/0000-0002-9220-3352)
- Álvaro Díaz‐González (ORCID: https://orcid.org/0000-0002-3362-0316)
- Alberto Miralles
- Sandra de las Heras
- Gayane Avetisyan
Institutions
- Hospital Universitari i Politècnic La Fe (ES)
- Hospital General Universitario de Alicante Doctor Balmis (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- Instituto de Investigación Sanitaria La Fe (ES)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1038/s41416-025-03204-0
- Citations
- 1
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- Ministerio de Ciencia e Innovación