Five CGD-Linked CYBB Mutations in Chinese Patients: Insights Into Predicting IFN-γ Treatment Efficacy
Our findings underscore the diverse effects of CYBB mutations on protein expression and function. More importantly, they suggest that assessing the IFN-γ-mediated potentiation of respiratory burst response in patient's neutrophils is an effective way to predict the therapeutic efficacy of IFN-γ in treating CGD cases, particularly those with non-tuberculous mycobacteria (NTM) and Mycobacterium tuberculosis (TB).
Authors
- Jinqiao Sun (ORCID: https://orcid.org/0000-0001-9125-8581)
- Di Tian (ORCID: https://orcid.org/0000-0002-6879-6629)
- Yixin Liao (ORCID: https://orcid.org/0000-0001-6997-6376)
- Xiuqing Guo
- Tiefu Liu (ORCID: https://orcid.org/0000-0002-1264-3068)
- Lu Xia
- Xiaohong Fan (ORCID: https://orcid.org/0000-0003-0265-7279)
- Satoshi Okada (ORCID: https://orcid.org/0000-0003-2776-9509)
- Yun Ling (ORCID: https://orcid.org/0000-0002-4289-3594)
- Lipin Liu (ORCID: https://orcid.org/0000-0003-3893-4661)
- Yabin Liu (ORCID: https://orcid.org/0000-0003-4970-7069)
- Dongling Shi (ORCID: https://orcid.org/0000-0001-9077-2271)
- Xinhua Li (ORCID: https://orcid.org/0000-0002-6748-9803)
- Feifei Wang (ORCID: https://orcid.org/0000-0001-8502-966X)
- Ping Liu (ORCID: https://orcid.org/0000-0002-6152-4508)
- Mei Xue (ORCID: https://orcid.org/0000-0003-0039-855X)
- Xiaochuan Wang (ORCID: https://orcid.org/0000-0002-7497-1622)
- Li Xu (ORCID: https://orcid.org/0000-0002-7883-0448)
- Chen Zhao (ORCID: https://orcid.org/0000-0002-0718-7707)
Institutions
- Hiroshima University (JP)
- Shanghai Medical College of Fudan University (CN)
- Sun Yat-sen University (CN)
- Shanghai Public Health Clinical Center (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Children's Hospital of Fudan University (CN)
- Hubei University (CN)
Publication Details
- Journal
- Journal of Clinical Immunology
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1007/s10875-025-01926-7
- Citations
- 1
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.80