The impact of different neoadjuvant radiotherapy doses on survival outcomes and toxicity in patients with locally advanced rectal cancer
Compared to the control group, the experimental group, which utilized a reduced radiation dose for the pelvic lymphatic drainage area, achieved a significantly lower incidence of ≥ 3 grade acute adverse reactions, fewer perioperative complications, and a higher preventive ileostomy reversal rate without any severe perioperative mortality, thereby enhancing the patients' quality of life, without compromising short-term efficacy or survival outcomes.
Authors
- Xuming Duan
- Weiting Huang (ORCID: https://orcid.org/0000-0003-3453-2374)
- Yanli Qu (ORCID: https://orcid.org/0000-0002-7533-6815)
- Yuchen Shen (ORCID: https://orcid.org/0000-0002-1181-5198)
- Deyu Sun (ORCID: https://orcid.org/0009-0007-2871-8750)
- Yan Li (ORCID: https://orcid.org/0000-0002-9935-2967)
- Hujian Hong
Institutions
- Dalian University of Technology (CN)
- Liaoning Cancer Hospital & Institute (CN)
- China Medical University (CN)
Publication Details
- Journal
- Radiation Oncology
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1186/s13014-025-02726-4
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Dalian University of Technology