CVID Enteropathy Is Difficult To Treat and Shows a Heterogeneous Histopathology
In this study, we describe a cohort of CVID-E patients including related comorbidity, clinical course and response to therapy. CVID-E patients frequently develop other, sometimes severe comorbidities. Our study confirms the alleged heterogeneity regarding endoscopic and histopathological findings, and in one third of patients even multiple distinct abnormalities co-occurred in the same biopsy. We found azathioprine and/or TNFi to be the most effective current treatment.
Authors
- Joris M. van Montfrans (ORCID: https://orcid.org/0000-0001-6764-0211)
- Pauline M. Ellerbroek
- Virgil A. S. H. Dalm (ORCID: https://orcid.org/0000-0001-5945-4435)
- Miangela M. Laclé (ORCID: https://orcid.org/0000-0003-3466-3569)
- Norsham Juliana (ORCID: https://orcid.org/0000-0001-8660-5593)
- Mirjam Severs
- J. Marsden (ORCID: https://orcid.org/0009-0008-8503-4969)
- Helen L. Leavis (ORCID: https://orcid.org/0000-0001-8720-3684)
- Amir Abelmoumen
Institutions
- Radboud University Nijmegen (NL)
- Utrecht University (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- University Medical Center Utrecht (NL)
Publication Details
- Journal
- Journal of Clinical Immunology
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1007/s10875-025-01920-z
- Citations
- 2
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.59