Duration of Current Statin Use and Amyotrophic Lateral Sclerosis Risk
The strong association between short-term current statin use and increased ALS risk is consistent with reverse causality, where statin initiation in the prediagnostic phase may occur when lipid levels rise and individuals seek medical attention due to emerging ALS symptoms. Long-term statin use was associated with reduced risk of ALS in men.
Authors
- Ola Nakken (ORCID: https://orcid.org/0000-0003-4765-0636)
- Trygve Holmøy (ORCID: https://orcid.org/0000-0002-2529-5664)
- Helmut E. Meyer (ORCID: https://orcid.org/0000-0002-3262-8260)
- Kjetil Bjørnevik (ORCID: https://orcid.org/0000-0002-2892-6986)
- Anders Myhre Vaage (ORCID: https://orcid.org/0000-0002-4995-7722)
- Hein Stigum
Institutions
- Norwegian Institute of Public Health (NO)
- Harvard University (US)
- University of Oslo (NO)
- Akershus University Hospital (NO)
Publication Details
- Journal
- Neurology
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1212/wnl.0000000000214221
- Citations
- 1
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.81