Identification of Skin Multicellular Reprogramming Factors as Potential Treatment for Nonhealing Diabetic Foot Ulcers
In this work, we identified a set of candidate TFs with the potential to induce a cell state transition favoring a switch from nonhealing to healing outcomes in patients with nonhealing DFU. Overall, our gene regulatory network-driven TF cocktail provides a rational blueprint for reprogramming DFU cell states and paves the way toward targeted regenerative therapies.
Authors
- Ahmed Abdellatif (ORCID: https://orcid.org/0000-0003-0486-348X)
- Sara Abouzekry (ORCID: https://orcid.org/0000-0001-6069-8760)
- Hossam Sharara (ORCID: https://orcid.org/0000-0003-0042-9790)
- Chandan K. Sen (ORCID: https://orcid.org/0000-0003-3151-5202)
- Ahmed A. Elbaz (ORCID: https://orcid.org/0000-0003-0502-0046)
- Ahmed Moustafa (ORCID: https://orcid.org/0000-0002-0111-3555)
- Ahmed S. Abouhashem (ORCID: https://orcid.org/0000-0003-1331-0123)
- Sherine K. Saber
- Kanhaiya Singh (ORCID: https://orcid.org/0000-0002-4126-9618)
- Mohammed Elkholy
Institutions
- McGowan Institute for Regenerative Medicine (US)
- Ministry of Health and Population (EG)
- American University in Cairo (EG)
Publication Details
- Journal
- Advances in Wound Care
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1177/21621918251376348
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00