Sex differences in ventricular muscle energetics in a type 2 diabetic rat model
Effects of type 2 diabetes do not manifest in the mechanoenergetic functional performance of isolated cardiac muscles, even when challenged to a wide range of loading conditions. This conclusion is upheld in both male and female rats. These findings underscore the need for assessing cardiac function beyond the muscle level, as muscle-specific thermodynamics in diabetes may not be captured from systemic whole-organism measurements.
Authors
- June‐Chiew Han (ORCID: https://orcid.org/0000-0002-6396-7628)
- Kenneth Tran (ORCID: https://orcid.org/0000-0002-8651-3557)
- David J. Crossman (ORCID: https://orcid.org/0000-0003-3811-5455)
- Andrew J. Taberner (ORCID: https://orcid.org/0000-0002-0452-0308)
- Linley A. Nisbet
- Maryam Rahmani (ORCID: https://orcid.org/0000-0002-9996-447X)
- Toan Pham (ORCID: https://orcid.org/0000-0002-6323-9217)
Institutions
- University of Auckland (NZ)
Publication Details
- Journal
- Cardiovascular Diabetology – Endocrinology Reports
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1186/s40842-025-00236-6
- Citations
- 1
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Royal Society Te Apārangi
- Health Research Council of New Zealand