Post hoc analysis of daratumumab plus lenalidomide, bortezomib and dexamethasone in Black patients from final data of the GRIFFIN study
Due in part to racial disparities and underrepresentation in clinical studies, optimal therapies for Black patients with multiple myeloma remain undefined. This final analysis of GRIFFIN by race showed that the addition of daratumumab (D) to lenalidomide/bortezomib/dexamethasone (RVd) provides clinical benefit among both Black and White transplant-eligible newly diagnosed patients compared with RVd alone. However, Black patients were more likely to discontinue ≥1 drug due to treatment-emergent adverse events. In summary, these findings suggest a benefit of D-RVd front-line therapy among Black and White patients and underscore the importance of equitable treatment access for all patients.
Authors
- Sarah A. Holstein (ORCID: https://orcid.org/0000-0002-9342-5635)
- Ajai Chari (ORCID: https://orcid.org/0000-0002-0405-7480)
- Saad Z. Usmani (ORCID: https://orcid.org/0000-0002-5484-8731)
- Ajay K. Nooka (ORCID: https://orcid.org/0000-0003-4165-6869)
- Larry D. Anderson (ORCID: https://orcid.org/0000-0002-6531-9595)
- Leyla Shune (ORCID: https://orcid.org/0000-0003-1650-1873)
- Paul Gerard Guy Richardson (ORCID: https://orcid.org/0000-0002-7426-8865)
- Huiling Pei (ORCID: https://orcid.org/0000-0001-5457-9191)
- Brandi Reeves (ORCID: https://orcid.org/0000-0002-2106-3698)
- Yvonne A. Efebera (ORCID: https://orcid.org/0000-0002-4163-8823)
- Ashraf Badros (ORCID: https://orcid.org/0000-0003-1690-0188)
- Annelore Cortoos
- Peter Michael Voorhees (ORCID: https://orcid.org/0000-0003-1661-718X)
- Jonathan L. Kaufman (ORCID: https://orcid.org/0000-0002-5687-6429)
- Tanya M. Wildes (ORCID: https://orcid.org/0000-0002-1479-7626)
- Sharmila Patel
- César A. Rodríguez (ORCID: https://orcid.org/0000-0003-3484-4829)
- Andrzej J. Jakubowiak (ORCID: https://orcid.org/0000-0002-4550-4726)
- Thomas S. Lin
Institutions
- University of North Carolina at Chapel Hill (US)
Publication Details
- Journal
- UNC Libraries
- Published
- 2025-04-05
- DOI
- https://doi.org/10.17615/tp8j-pd73
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00