Cinnamaldehyde triggers cell wall remodeling and enhances macrophage-mediated phagocytic clearance of Candida albicans
Mechanistically, CIN induces β-1,3-glucan exposure on <i>C. albicans</i>, thereby promoting Dectin-1-mediated phagocytosis and clearance. These findings provide an experimental basis for developing CIN as a novel antifungal therapeutic.
Authors
- Zhaoling Shi
- Kelong Ma (ORCID: https://orcid.org/0000-0001-5111-0515)
- Jiajia Lin (ORCID: https://orcid.org/0000-0003-1468-7344)
- Feng Chen (ORCID: https://orcid.org/0000-0003-3508-8834)
- Yue Yang (ORCID: https://orcid.org/0000-0002-6201-8818)
- Wenqian Li (ORCID: https://orcid.org/0000-0001-6482-6010)
- Wenna Zhang (ORCID: https://orcid.org/0000-0002-2096-8321)
Institutions
- Anhui University of Traditional Chinese Medicine (CN)
- Hefei Institutes of Physical Science (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-09-15
- DOI
- https://doi.org/10.3389/fcimb.2025.1647320
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Anhui University
- Anhui University of Chinese Medicine
- Natural Science Foundation of Anhui Province