Clonal hematopoiesis driven by Dnmt3a mutations promotes metabolic disease development in mice
#ClonalHematopoiesis, an #aging related condition caused by mutations in the #blood system, promotes #obesity, and with high-fat #diet drives the risk of #diabetes and #MASLD.
Authors
- Annalisse R. McKee
- Alexander G. Bick (ORCID: https://orcid.org/0000-0001-5824-9595)
- Caitlyn Vlasschaert (ORCID: https://orcid.org/0009-0003-8466-7602)
- Olga A. Guryanova (ORCID: https://orcid.org/0000-0002-6514-8466)
- Daniil E. Shabashvili (ORCID: https://orcid.org/0000-0003-4066-7953)
- Qingchen Yuan (ORCID: https://orcid.org/0000-0003-4999-3931)
- Michael J. Rauh (ORCID: https://orcid.org/0000-0002-8346-5537)
- Marco M. Buttigieg (ORCID: https://orcid.org/0000-0002-9584-9861)
- Prabhjot Kaur
- Bowen Yan (ORCID: https://orcid.org/0000-0003-4730-6763)
Institutions
- Queen's University (CA)
- University of Florida Health (US)
- University of Florida (US)
- UF Health Cancer Center
- Vanderbilt University Medical Center (US)
- Florida College (US)
Publication Details
- Journal
- Journal of Clinical Investigation
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1172/jci197100
- Citations
- 2
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.25