Chlorobactine A, a Dimeric Dichlorated Metabolite from Marine-Derived <i>Streptomyces thermolineatus</i> NAK03196
Using the one strain many compounds (OSMAC) strategy and guided by LC-MS results, we explored the metabolites of marine algae-derived strain <i>Streptomyces thermolineatus</i> NAK03196 and discovered a new class of molecules with an unexpected skeleton, chlorobactine A (<b>1</b>). Its structure was determined by 1D and 2D NMR spectroscopy, HR-ESI-MS, single-crystal X-ray diffraction analysis (Cu Kα), and ECD calculation. Chlorobactine A (<b>1</b>) contains dichlorine atoms and possesses a unique [6/6/6] tricyclic fused skeleton structure. Meanwhile, a plausible biosynthetic pathway for <b>1</b> was proposed based on the molecular structures and bioinformatic analysis.
Authors
- Guodong Zhang (ORCID: https://orcid.org/0000-0003-4487-1820)
- Rui‐Hua Jiao
- Xiaoguang Yang (ORCID: https://orcid.org/0000-0002-9880-3682)
- Wen Wang (ORCID: https://orcid.org/0000-0002-3709-021X)
- Zi Xiong (ORCID: https://orcid.org/0000-0002-8528-9207)
- Rong Wang (ORCID: https://orcid.org/0000-0001-9501-0348)
- Chao Zhang (ORCID: https://orcid.org/0000-0003-4580-1381)
- Shuai Ma (ORCID: https://orcid.org/0000-0003-0918-6510)
- Zhikai Guo (ORCID: https://orcid.org/0000-0002-9608-0847)
- Jing Bo Shi (ORCID: https://orcid.org/0000-0002-9257-6060)
Institutions
- Chinese Academy of Tropical Agricultural Sciences (CN)
- Nanjing Agricultural University (CN)
- Hainan Provincial Academy of Marine Fisheries and Aquaculture (CN)
- Tropical Crops Genetic Resources Institute (CN)
- Pharmaceutical Biotechnology (Czechia) (CZ)
- State Key Laboratory of Pharmaceutical Biotechnology
- Nanjing University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1021/acs.orglett.5c03588
- Citations
- 1
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 1.39