Exploring the Interaction Between Injection Site and Biological Sex on the Real-world Population Pharmacokinetics of Long-acting Cabotegravir and Rilpivirine in People With HIV
Subcutaneous depot deposition after intramuscular injections is not uncommon, occurring more frequently in females and is associated with increased skin to muscle thickness. Slower absorption of cabotegravir from subcutaneous administration contributes to the observed sex differences in drug concentrations.
Authors
- Sam Salman (ORCID: https://orcid.org/0000-0002-8276-6784)
- David A. Joyce (ORCID: https://orcid.org/0000-0002-7080-3293)
- Seán O’Halloran (ORCID: https://orcid.org/0009-0004-1482-4120)
- Benedict Tan (ORCID: https://orcid.org/0000-0002-1098-2242)
- Mina John (ORCID: https://orcid.org/0000-0002-6429-0719)
- D. Nolan
- Alison Castley
- Leah Williams
Institutions
- Murdoch University (AU)
- The University of Western Australia (AU)
- Royal Perth Hospital (AU)
- Pathwest Laboratory Medicine (AU)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-09-28
- DOI
- https://doi.org/10.1093/ofid/ofaf614
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00