Whole-genome sequencing reveals complex structural variations at a major locus linked to pigmented spot sizes in Tianfu goats
We identified a genomic region with complex SVs near EDNRA on chromosome 17 as a major locus influencing pigmented spot sizes in TF goats. We further pinpointed the causal mutations to an approximately 80-kb inverted duplication. Additionally, we detected a strong secondary association signal on chromosome 4. Our findings deepen the understanding of genetic variations underlying pigmentation in goats and provide valuable insights for selective breeding and conservation efforts.
Authors
- Quanjun Xiang (ORCID: https://orcid.org/0000-0002-4486-7429)
- Xihong Wang (ORCID: https://orcid.org/0000-0002-8277-969X)
- Hong Ping Zhang (ORCID: https://orcid.org/0000-0003-4312-0099)
- Qiuyang Huang (ORCID: https://orcid.org/0000-0002-0000-6635)
- George E. Liu (ORCID: https://orcid.org/0000-0003-0192-6705)
- Peipei Bian (ORCID: https://orcid.org/0000-0002-3948-4052)
- Jiazhong Guo (ORCID: https://orcid.org/0000-0001-9773-2280)
- Li Li (ORCID: https://orcid.org/0000-0002-9953-7785)
- Guo Hao Wu
Institutions
- Agricultural Research Service (US)
- Sichuan Agricultural University (CN)
- Northwest A&F University (CN)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s12864-025-12055-1
- Primary Topic
- melanin and skin pigmentation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Agriculture
- European Commission
- Natural Science Foundation of Sichuan Province
- National Institute of Food and Agriculture