PHLPP1 deficiency alleviates dopaminergic neurodegeneration and represses neuroinflammation in Parkinson’s disease
Our results demonstrates that PHLPP1 knockout in PD model is positively associated with the survival of TH + neurons by suppressing inflammatory response in substantia nigra, suggesting that PHLPP1 plays a critical role in the development of PD.
Authors
- Xin‐Fu Zhou (ORCID: https://orcid.org/0000-0002-8687-0175)
- Zikai Zhou (ORCID: https://orcid.org/0000-0002-4577-9826)
- Yudi Han
- Huazheng Liang (ORCID: https://orcid.org/0000-0001-9097-7357)
- Yuan Liu (ORCID: https://orcid.org/0000-0001-5031-7514)
- Yong Bi
- Zhilin Chen (ORCID: https://orcid.org/0000-0003-4594-2731)
- Jinyue Zhao
Institutions
- Tongji University (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Materia Medica (CN)
- Suzhou Research Institute (CN)
- Shanghai University of Medicine and Health Sciences (CN)
- Tongji Hospital (CN)
- Shanghai Center for Brain Science and Brain-Inspired Technology (CN)
Publication Details
- Journal
- Behavioral and Brain Functions
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s12993-025-00293-y
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Shanghai Pudong New Area Health Commission