Comparison of pathological features of patients with antibody-negative and positive primary biliary cholangitis
The pathological symptoms and diagnostic patterns of autoantibody-negative and positive PBC were generally comparable. In this study, the pathological manifestations of antibody-negative PBC were similar to those of antibody-positive PBC, but the lymphocyte aggregation in antibody-negative PBC was more severe than that in antibody-positive PBC, while the degree of bile duct injury and CK7-positive hepatocytes were milder than that in antibody-positive PBC, suggesting that the overall pathological changes of antibody-negative PBC were slightly milder than those of antibody-positive PBC.
Authors
- Hong-Li Liu
- Siwei Zheng (ORCID: https://orcid.org/0000-0002-9771-7379)
- Wenquan Zeng
- Xiaoning Feng (ORCID: https://orcid.org/0000-0003-0113-7626)
- Du-Xian Liu
- Ping Huang (ORCID: https://orcid.org/0000-0002-4931-4663)
- Yan-Dan Zhong (ORCID: https://orcid.org/0000-0003-4580-9375)
- Yifan Hu (ORCID: https://orcid.org/0000-0003-0756-6157)
- Yijun Bao (ORCID: https://orcid.org/0000-0002-2149-0112)
- Kai Zhang (ORCID: https://orcid.org/0000-0002-3595-3659)
- Li Wang (ORCID: https://orcid.org/0000-0002-9995-7122)
- Shasha Li (ORCID: https://orcid.org/0000-0003-4198-2314)
- Xue Wang (ORCID: https://orcid.org/0009-0000-0201-3938)
- Yongfeng Yang (ORCID: https://orcid.org/0000-0002-3214-0038)
- Yu Zhang (ORCID: https://orcid.org/0000-0002-0694-6409)
- Caiyun Zhang (ORCID: https://orcid.org/0000-0002-9570-0207)
- Qingfang Xiong (ORCID: https://orcid.org/0000-0003-2743-555X)
- Xing Liu (ORCID: https://orcid.org/0000-0003-1036-5858)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Nanjing Second Hospital (CN)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s12876-025-04280-5
- Citations
- 1
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 1.32
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Government of Jiangsu Province
- China Scholarship Council
- Natural Science Foundation of Jiangsu Province