MiR-7683-3p from M2-exosomes attenuated atherosclerosis by activating the PPARγ-LXRα-ABCG1 pathway mediated cholesterol efflux of vascular smooth muscle cell derived foam cells
M2-exos exerted an obvious atherosclerotic protective effect, and the underlying mechanism was closely related to MiR-7683-3p, which targeted the 3'UTR of HOXA1 mRNA and activated the PPARγ-LXRα-ABCG1 mediated cholesterol efflux in VSMC-FCs.
Authors
- Tiejun Pan (ORCID: https://orcid.org/0000-0002-9193-7362)
- Yongchun Cui (ORCID: https://orcid.org/0000-0002-2375-5778)
- Zhenhao Zhang
- Yunhui Lv (ORCID: https://orcid.org/0000-0001-7243-739X)
- Y. Zhang
- Jiafei Li
- Peihe Wang (ORCID: https://orcid.org/0000-0003-1144-729X)
- Shilei Wen (ORCID: https://orcid.org/0000-0002-2699-9954)
- Fengqing Zhang (ORCID: https://orcid.org/0000-0001-8405-6228)
- Xiaohu Wang (ORCID: https://orcid.org/0000-0002-5073-0488)
- Xiaodong Hao (ORCID: https://orcid.org/0000-0001-5177-8646)
- Qi Zhang (ORCID: https://orcid.org/0000-0002-6530-5927)
- Haotian Zhang (ORCID: https://orcid.org/0000-0001-8521-1744)
- Ting He (ORCID: https://orcid.org/0000-0002-6338-3622)
- Shuo Wang (ORCID: https://orcid.org/0000-0003-3897-7899)
- Hong Lian (ORCID: https://orcid.org/0000-0003-4980-4870)
- Xianqiang Wang (ORCID: https://orcid.org/0000-0003-0602-6765)
- Jiangping Song
- Jian Meng
- MA Chi Yung
Institutions
- Macau University of Science and Technology (MO)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fu Wai Hospital (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s12951-025-03690-7
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61