Profile, Infection, and Vaccination Uptake: A Cohort of Canadian Retail Workers During the SARS-CoV-2 Pandemic

<i>Background/Objectives:</i> Retail workers may have been at an increased risk of contracting SARS-CoV-2 during the COVID-19 pandemic. To better understand this group, we set up a longitudinal cohort to document the occurrence of SARS-CoV-2 infection, vaccination uptake and to study immune response. <i>Methods:</i> Participants were enrolled between 20 April and 22 October 2021 and attended up to 5 visits over 48 weeks. Information collected was: participant characteristics, SARS-CoV-2 detection tests performed, COVID-19 symptoms, and vaccination (influenza and SARS-CoV-2). <i>Findings:</i> We included 304 participants aged 18 to 75; of those, 117 had a first positive SARS-CoV-2 test, mostly (85.5%) during Omicron wave. Forty-two (13.8%) participants got seasonal influenza vaccine within the year (2020-2021) prior to the first visit, and 95.9% had received the primary series of 2 doses of SARS-CoV-2 vaccine by the beginning of Omicron wave. Participants vaccinated for influenza (adjusted hazard ratio (aHR) 2.48; 95% confidence interval (CI): 1.54-3.98) and older patients (aHR 2.39; 95% CI: 1.40-4.10), were more likely to get a first booster of SARS-CoV-2 vaccine compared to those who did not receive influenza vaccine. In contrast, participants who traveled (aHR 0,62; 95% CI: 0.43-0.91) or participated in frequent gatherings (aHR 0.58; 95% CI: 0.39-0.85) were less likely to be boosted. <i>Conclusions:</i> Variations in vaccine uptake that are usually observed within populations had little effect on completion of the primary SARS-CoV-2 vaccine series. However, these differences became apparent for booster doses, at a period during which most infections in this cohort were recorded.