The Role of LEF1 Protein in Chronic Lymphocytic Leukemia and Different Treatment Methods

A subtype of white blood cells called lymphocytes is the source of chronic lymphocytic leukemia (CLL), a malignancy of the bone marrow and blood.A single lymphocyte can transform into a cancer cell, proliferate over time, and finally displace normal lymphocytes in the lymph nodes and bone marrow.These cells can no longer fight infection, in contrast to normal lymphocytes.It has been demonstrated that lymphoid enhancer-binding factor-1 (LEF1), a member of the LEF/TCF transcription factor family, plays an essential role in regulating Wnt-pathway target genes.LEF1 plays a crucial role in many cancers.Recent studies have shown that LEF1 is overexpressed in CLL.LEF1 is specifically expressed at early stages of B-cell differentiation and is essential for survival and proliferation.In this review, the general course of the disease in CLL, the applied treatment strategies and the role of the LEF1 protein are analyzed in the light of current studies.