Optimization and characterization of acute radiation-induced esophagitis in mice
In this study, we found that a single 20 Gy thoracic irradiation was the optimal dose to establish acute RIE in C57BL/6 mice. Acute esophageal injury peaked on Day 7 after radiation, and the process of regeneration and repair was complete within 14 days. This work may be a useful reference for experimental research concerning RIE.
Authors
- Dengqun Liu (ORCID: https://orcid.org/0000-0003-3135-8067)
- Simin He
- Jinyi Lang (ORCID: https://orcid.org/0000-0002-5406-8671)
- Xudan Lei (ORCID: https://orcid.org/0000-0002-0345-4302)
- Yujun Huang (ORCID: https://orcid.org/0000-0002-2763-6776)
- Jun Yin (ORCID: https://orcid.org/0009-0008-5428-9969)
- Lu Xu (ORCID: https://orcid.org/0000-0002-6013-0742)
- Xi Wang (ORCID: https://orcid.org/0000-0002-2885-4388)
- Zhenni Xu (ORCID: https://orcid.org/0009-0008-3478-4786)
- Shubin Wang (ORCID: https://orcid.org/0000-0001-6790-6745)
- Xiangjun Liu (ORCID: https://orcid.org/0000-0002-8413-2451)
- Lingxiao Huang (ORCID: https://orcid.org/0000-0001-7512-142X)
- Ke Wang (ORCID: https://orcid.org/0000-0003-1487-190X)
- Jianhua Feng (ORCID: https://orcid.org/0000-0003-1570-7626)
Institutions
- Third People's Hospital of Chengdu (CN)
- Fourth People's Hospital of Sichuan Province (CN)
- Affiliated Hospital of North Sichuan Medical College (CN)
- Sichuan Cancer Hospital (CN)
Publication Details
- Journal
- Radiation Oncology
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1186/s13014-025-02720-w
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Department of Science and Technology of Sichuan Province