Influence of TPH2 DNA methylation and family functioning, parenting styles on OCD severity
DNA methylation at specific CpG sites in the TPH2 promoter region may play a critical role in the pathogenesis and symptom severity of OCD. Methylation patterns also correlated with family functioning and parenting styles. These findings suggest that TPH2 methylation may mediate the link between adverse family environments and OCD, possibly through reduced serotonin synthesis and impaired emotion regulation. Our results support a gene-environment interaction model contributing to OCD vulnerability.
Authors
- D. Qiao (ORCID: https://orcid.org/0000-0002-2754-7087)
- Tiangui Yu (ORCID: https://orcid.org/0000-0002-4407-0639)
- Zhihong Liu (ORCID: https://orcid.org/0000-0001-6093-0726)
- Shiqi Hu
- Yu Chen (ORCID: https://orcid.org/0000-0002-2825-6767)
- Lina Wang (ORCID: https://orcid.org/0009-0008-1750-5191)
Institutions
- Shandong University (CN)
- Capital Medical University (CN)
- Shandong Normal University (CN)
- Beijing Anding Hospital (CN)
- Shandong Mental Health Center (CN)
Publication Details
- Journal
- BMC Psychiatry
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1186/s12888-025-07217-0
- Primary Topic
- Obsessive-Compulsive Spectrum Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00